Cape Girardeau is a city in Cape Girardeau and Scott counties in the U.S. state of Missouri. It is located approximately southeast of St. Louis and north of Memphis. As of the 2017 United States Census Bureau estimates, the city's population was 39,151, making it the 17th-largest city in Missouri, and the largest city in Southeast Missouri. An emerging college town, it is the home of Southeast Missouri State University.
Phone Area Codes in Cape Girardeau, MO: 573

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